In the face of increasing bacterial drug resistance because of β-lactamase production, many microbial infections can be treated effectively by combining clavulanic acid with amoxicillin. Judicious drug use that includes defining the optimum dosage is important to control development of resistance to this drug combination. In this study, amoxicillin and clavulanic acid were administered to blue-fronted Amazon parrots (Amazona aestiva aestiva) in a multiple dosing trial. Birds were gavaged with 125 mg/kg of the drug combination at 0800, 1600, and 2200 hours on days 1–5. The half-lives of amoxicillin and clavulanic acid were similar to those in humans; however, the area under the curve was increased in the parrots compared with humans. These results suggest that this drug combination, at this dosing interval, achieves levels that may be effective against many bacterial species.